
In 1950 she came to Mumbai and made her film debut in Tangewali in 1955. For Goonj Uthi Shehnao (1959), she earned her only Filmfare nomiation of her career as Best Supporting Actress.
Even Anita Guha claimed that many people came to her asking her to bless them, as they thought her to be a real goddess.
Anita Guha acted in mythological films in Dekh Kabira Roya (1957), Kavi Kalidas (1959), Jai Dwarkadesh (1977) and Krishna Krishna (1986).